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KMID : 0359319950350040753
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Korean Journal of Veterinary Research
1995 Volume.35 No. 4 p.753 ~ p.758
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Studies on isolation of rhinopneumonitis virus from Korean horses and its immunogenicity III. Studies on immunogenicity of equine herpesvirus in experimental animals
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Cho Gil-Jae
Kim Bong-Hwan
So Sin-Hee
Lee Du-Sik
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Abstract
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The study was carried out to investigate the pathogenicity of EHV isolate to hamsters and mice and immunogenicity of experimentally produced. vaccine were evaluated in the horses. Hamsters infected. intranasally with LC1 isolate showed symptoms of nasal discharge, conjunctivitis and body weight loss during the observation period of 12 days after infection, while only slight depression and body weight loss were noticed with mice infected with LC1 indicating that hamsters are more susceptible to the virus. Antibody titer of mice and hamsters were gradually increased to highest level of 1:2560~10240, 1:640~1280, respectively, at 7~12 days post vaccination. Horses immunized against LC1 killed vaccine reached to maximum antibody titer of 1:20480 around 4 weeks after 1st vaccination and declined after 12 weeks post vaccination. No significant antibody increase were detected after 2nd vaccination. Mean body temperature and mean total leukocyte counts remained within normal range and no adverse reaction were noticed after vaccination.
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KEYWORD
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EHV , hamster , nasal discharge , conjunctivitis , mice
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